Scientists discover a hidden force that helps wire the brain

Growing neurons rely on chemical cues to find their targets, but new research shows that the brain’s physical properties help shape those signals. Scientists discovered that tissue stiffness can trigger the production of guidance molecules through a force-sensing protein called Piezo1. This protein not only detects mechanical forces but also helps maintain the structure of brain tissue. The discovery reveals a powerful link between the brain’s physical environment and how its wiring is built. Until now, scientists have not fully understood how these two types of guidance work together. An international research team has discovered that the stiffness of brain tissue can control the production of important signalling molecules. The findings... [4574 chars]