Researchers developed optimized all-RNA lipid nanoparticles that delivered prime editor mRNA, epegRNA, and nicking gRNA to mouse liver, achieving 49% average Pcsk9 prime editing after one systemic dose. A non-viral lipid nanoparticle system delivered three RNA editing components to liver cells, suggesting a preclinical path toward precise, repeat-dose correction of inherited metabolic diseases. AI-generated illustration created using ChatGPT/OpenAI,... [6553 chars]
ADVERTISEMENT
ADVERTISEMENT
2026 Copyright © News-Matic.com. All Rights Reserved
